Proton Pump
The proton pump is an integral membrane protein that is capable of moving protons across a biological membrane. Mechanisms are based on conformational changes of the protein structure or on the Q cycle. In cell respiration, the proton pump uses energy to transport protons from the matrix of the mitochondrion to the inter-membrane space. The proton pump does not create energy, but forms a gradient that stores energy for later use.
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Tolcapone是一种有效和选择性的可逆硝基酚类儿茶酚-O-甲基转移酶(COMT)抑制剂,Ki为30nM。
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A922500是人类和小鼠DGAT-1抑制剂,IC50分别为7 nM和24 nM,比作用于相关的酰基转移酶,hERG及抗靶面板的选择性高。
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OSI-930是Kit,KDR和CSF-1R的抑制剂,IC50分别为80 nM,9 nM和15 nM,对Flt-1,c-Raf和Lck有接近的抑制性,但对 PDGFRα/β,Flt-3和Abl抑制性较弱。
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Tylosin酒石酸盐是大环内酯类抗生素。
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Chloramphenicol是广谱抗菌剂。
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